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The Stem Cell Podcast

Ep. 18: Lou Gehrig’s Update Featuring Dr. Kevin Eggan

May 13, 2014
Dr. Kevin Eggan, a professor at Harvard, is on a mission to tackle ALS using stem cells. He shares groundbreaking insights into the role of the C9orf72 gene, often overlooked in ALS research. The conversation dives into environmental factors linked to the disease, exploring intriguing cases involving athletes and military personnel. Eggan also highlights the challenges in replicating scientific studies and the desperate need for funding to advance innovative research in this vital field. Exciting findings promise hope for future ALS treatments!
01:13:04

Episode guests

Podcast summary created with Snipd AI

Quick takeaways

  • Stem cell research is crucial for understanding ALS mechanisms, particularly through the development of disease models using induced pluripotent stem cells (iPSCs).
  • The C9orf72 gene mutation significantly contributes to ALS variability, highlighting the importance of personalized diagnosis and treatment strategies.

Deep dives

Overview of ALS and Stem Cell Research

Amyotrophic lateral sclerosis (ALS), commonly known as Lou Gehrig's disease, is a progressive neurodegenerative condition that initially affects motor neurons, leading to muscle weakness and atrophy. Research using stem cells has provided new insights into understanding the disease's mechanisms. Studies have highlighted that ALS can stem from genetic mutations, with approximately 10% of cases inherited from family history, while the remaining 90% remain idiopathic. The field has made significant advancements through induced pluripotent stem cell (iPSC) technology, allowing researchers to create disease models that can specifically address ALS and investigate potential therapeutic interventions.

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