Locked On 49ers - Daily Podcast On The San Francisco 49ers

49ers Keys to Victory vs the Los Angeles Rams in Week 10

Nov 7, 2025
The discussion kicks off with strategies to tackle Matthew Stafford, emphasizing the need for a strong pass rush despite injury challenges. They highlight crucial injuries on the defensive line and their potential impact on game strategy. The hosts reflect on the earlier Rams matchup and its relevance for this week. They also weigh in on whether the team should have made moves at the trade deadline. Predictions on quarterback performance and offensive strategies to maximize playmakers round out the conversation.
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INSIGHT

Stafford's Efficiency Raises Stakes

  • Matthew Stafford is playing at an unusually efficient, high level this season with 21 TDs and only 2 INTs.
  • That efficiency makes pressuring him a top priority for the 49ers' defensive game plan.
ADVICE

Make Pressure The Defensive Focus

  • Get consistent pressure and multiple sacks to rattle Stafford and force tougher throws.
  • Without reliable pressure, the 49ers risk letting Stafford exploit coverage and sustain drives.
INSIGHT

DL Injuries Cripple Pass Rush Depth

  • The 49ers' defensive line depth is thin after multiple injuries, which directly limits pass-rush options.
  • Keon White's availability is crucial because he's the lineman most likely to create pressure on his own.
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