In the week the Nobel prizes for science are announced, Roland Pease takes a look at the stories behind the breakthroughs being recognized, and the themes that connect them. From the discovery of the tiny fragments of RNA that regulate our cells’ behaviour, via computer structures that resemble our brains, and harnessing those sorts of computers to design drugs and medicines, it has been one of the most interdisciplinary years for the prize panellists.

We hear from old students, recent colleagues, laureates and lab (and life) partners, including Rosalind “Candy” Lee and her husband Victor Ambros, of UMass Chan Medical School, US, Erika DeBenedictus of the Crick Institute, UK, and Dmitri Krotov of IBM Research.

Presented: Roland Pease Produced: Alex Mansfield Production co-ordinator: Andrew Rhys Lewis

(Photo: 3d rendering of RNA strands and lipid-based nanoparticles or liposome. Credit: Love Employee via Getty Images)