CoinDesk Podcast Network Charles Hoskinson on Cardano’s Greatest Challenge, Why Ethereum Will Fail and His $200M Bet on American Healthcare | CoinDesk Spotlight
Sep 9, 2025
Charles Hoskinson, CEO and co-founder of Input Output and a key figure in Ethereum and Cardano, dives into the future of crypto. He boldly claims Ethereum may not survive the next decade and reveals Bitcoin DeFi as a 'sleeping giant.' The conversation shifts to his ambitious investments aimed at transforming American healthcare and even de-extincting species through synthetic biology. Hoskinson emphasizes the need for patient-centered solutions and discusses the disruptive potential of tech in both the crypto and healthcare sectors.
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From Dabbler To Professional Bitcoiner
- Charles Hoskinson went from dabbling in Bitcoin to becoming a professional Bitcoiner after events like Silk Road and the Cypriot crisis.
- He founded the Bitcoin Education Project and led education efforts through the Bitcoin Foundation.
Founders Need Clear Roles
- Hoskinson says Ethereum was Vitalik's project and required consolidation among founders to scale.
- He used those differences to build Cardano with distinct design choices like extended UTXO and on-chain governance.
Plan For Layer-Two Drift
- Expect layer-two ecosystems to drift away if they find better incentives elsewhere.
- Plan for pivoting and new value propositions when platform momentum shifts.