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The Curbsiders Internal Medicine Podcast
REBOOT #421 Antiphospholipid Syndrome with Dr. Arielle Langer
Jan 6, 2025
Dr. Arielle Langer, an assistant professor at Harvard Medical School and director of various specialized programs, dives into antiphospholipid syndrome's clinical features, testing, and management strategies. She breaks down the diagnostic challenges, emphasizing the need for precise differentiation between true cases and false positives. Langer also discusses the complexities of managing this condition, particularly in pregnancy, and highlights the importance of patient education and collaboration with specialists for optimal care.
01:20:37
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Quick takeaways
- Antiphospholipid syndrome (APS) is an autoimmune disorder that triggers unusual clots in young individuals lacking classic risk factors for thrombosis.
- The diagnosis of APS involves careful interpretation of antibody tests, as false positives can occur due to inflammatory conditions affecting accuracy.
Deep dives
Understanding Antiphospholipid Syndrome
Antiphospholipid syndrome (APS) is characterized as an autoimmune disorder where the body's immune system mistakenly activates clotting proteins instead of destroying them. This condition leads to increased thrombotic events, which can present variably in different patients. Recognition of APS involves identifying unusual clots in young individuals without typical risk factors such as atherosclerosis. These clots can occur in both venous and arterial systems, making a thorough clinical evaluation essential for accurate diagnosis.
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