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The Intern At Work: Internal Medicine
91. The Uninvited Granulomas - An Approach to Sarcoidosis
May 30, 2021
Learn all about Sarcoidosis, a disease of non-caseating granulomas that can appear in different parts of the body. Explore the associated symptoms like Heerfordt's Syndrome and Lofgren's Syndrome. Discover how diagnosis and treatment are approached in this systemic condition.
16:24
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Quick takeaways
- Sarcoidosis forms non-caseating granulomas triggered by an overactive immune response.
- Diagnostic approach involves blood work, imaging, and biopsy for sarcoidosis affecting multiple organs.
Deep dives
The Formation of Granulomas in Sarcoidosis
Sarcoidosis triggers an overactive immune response leading to non-caseating granulomas. When exposed to unknown antigens, CD4 cells secrete cytokines to form these protective granulomas. Unlike caseating granulomas from tuberculosis, sarcoidosis granulomas do not destroy cells, affecting various organs like lymph nodes, lungs, eyes, and skin.
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Discover
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