Researcher Dave Feldman discusses preliminary data from the lean mass hyper-responder study on elevated LDL while on a keto diet. They explore implications of high LDL levels, challenges the concept of a health risk threshold, and emphasize the importance of ongoing research and careful interpretation of data.
Study explores high LDL impact in lean mass hyper responders on keto diet.
Preliminary data shows lower plaque levels contradicting high LDL concerns.
Importance of cautious interpretation and longitudinal studies on atherosclerosis development.
Deep dives
Study on Lean Mass Hyper Responder Phenotype
A preliminary data release for the lean mass hyper responder study is discussed. Dave Feldman and Dr. Matt Boudoff are collaborating to measure plaque with a CT angiogram for those with elevated LDL following a ketogenic diet. At Low Carb San Diego, preliminary data was presented indicating excitement and pushback, with caution emphasized in interpreting the data.
Dave's Initiative in Organizing the Study
Dave Feldman, an engineer and citizen scientist, initiated the study to explore theories on LDL and atherosclerosis within a low-carb setting. His study aims to gather data on lean mass hyper responders, focusing on high LDL levels in participants following a ketogenic diet. The study has garnered interest but highlights the need for cautious interpretation of preliminary data.
Baseline Data and Participant Demographics
The preliminary data included baseline characteristics of 64 participants, average age of 53 and predominantly male. Initial analysis revealed lower-than-expected plaque levels, suggesting a healthy cohort despite high LDL. The study's unique focus on lean mass hyper responders aims to evaluate the impact of high LDL within this specific demographic.
Interpreting Early Data vs. Longitudinal Outcomes
Dave Feldman and Dr. Boudoff emphasized the preliminary nature of the data, cautioning against drawing conclusive outcomes. Early qualitative analysis on plaque scores revealed intriguing findings, supporting the need for longitudinal studies to compare baseline and follow-up data. The study intends to address questions on atherosclerosis development over time.
Safety Protocols and Study Duration
The study includes safety measures to address high-grade stenosis or significant findings promptly. While some criticize the one-year duration, Dr. Boudoff highlights the standard approach for plaque progression studies using CT angiograms. Matching participants and assessing outcomes over time will provide valuable insights into the impact of high LDL on cardiovascular health.
Dave Feldman released preliminary data from the lean mass hyper-responder study investigating elevated LDL while on a keto diet. What can we learn from the data thus far?
Get the Snipd podcast app
Unlock the knowledge in podcasts with the podcast player of the future.
AI-powered podcast player
Listen to all your favourite podcasts with AI-powered features
Discover highlights
Listen to the best highlights from the podcasts you love and dive into the full episode
Save any moment
Hear something you like? Tap your headphones to save it with AI-generated key takeaways
Share & Export
Send highlights to Twitter, WhatsApp or export them to Notion, Readwise & more
AI-powered podcast player
Listen to all your favourite podcasts with AI-powered features
Discover highlights
Listen to the best highlights from the podcasts you love and dive into the full episode