Business Trip cover image

Business Trip

The quest to improve MDMA

Dec 20, 2022
This podcast explores the development of new psychedelic compounds, the therapeutic potential of MDMA, and the challenges of running a psychedelic biotech company. It also discusses the potential applications and administration methods of psychedelic compounds, as well as initiatives to improve access to MDMA. Additionally, it delves into the rush of biotech companies going public and the concept of founder equity pledge in the psychedelic research field.
55:29

Podcast summary created with Snipd AI

Quick takeaways

  • Tactogen is developing an MDMA analogue that aims to be gentler and safer, with potential for at-home administration.
  • MDMA and related compounds, known as empathogens, stimulate monoamine transporters and release neurotransmitters like serotonin, dopamine, and norepinephrine, making the design of new compounds with MDMA-like effects more complex.

Deep dives

Developing new psychedelic compounds

Developing new psychedelic compounds presents both opportunities and challenges. On one hand, it allows for the improvement of the attributes of psychedelics in terms of safety and effectiveness in therapeutic settings. This includes making them faster acting or designing a smoother onset of the experience. On the other hand, making tweaks to first-generation psychedelics before they are FDA approved raises questions of whether it is getting ahead of the process. Tactogen, a drug development company, aims to create new chemical entities inspired by MDMA that are gentler and safer, with potential for administration in an at-home setting.

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