This podcast explores the development of new psychedelic compounds, the therapeutic potential of MDMA, and the challenges of running a psychedelic biotech company. It also discusses the potential applications and administration methods of psychedelic compounds, as well as initiatives to improve access to MDMA. Additionally, it delves into the rush of biotech companies going public and the concept of founder equity pledge in the psychedelic research field.
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Quick takeaways
Tactogen is developing an MDMA analogue that aims to be gentler and safer, with potential for at-home administration.
MDMA and related compounds, known as empathogens, stimulate monoamine transporters and release neurotransmitters like serotonin, dopamine, and norepinephrine, making the design of new compounds with MDMA-like effects more complex.
Tactogen envisions the possibility of administering entactogens in at-home settings for conditions like alcohol use disorder, PTSD, or social anxiety, expanding beyond the traditional therapy model.
Deep dives
Developing new psychedelic compounds
Developing new psychedelic compounds presents both opportunities and challenges. On one hand, it allows for the improvement of the attributes of psychedelics in terms of safety and effectiveness in therapeutic settings. This includes making them faster acting or designing a smoother onset of the experience. On the other hand, making tweaks to first-generation psychedelics before they are FDA approved raises questions of whether it is getting ahead of the process. Tactogen, a drug development company, aims to create new chemical entities inspired by MDMA that are gentler and safer, with potential for administration in an at-home setting.
MDMA: A unique compound
MDMA is often classified as a psychedelic, but it has distinct differences from classical psychedelics. While classical psychedelics stimulate the 5-H-T2A receptor and induce self-transcendent experiences, MDMA and related compounds have been recognized for their ability to generate a version of oneself that is less neurotic, allowing for clarity and emotional exploration. These compounds, known as entactogens or empathogens, stimulate monoamine transporters and interact with specialized neurons, releasing neurotransmitters like serotonin, dopamine, and norepinephrine. Unlike classical psychedelics, designing new compounds with MDMA-like effects is more complex due to the intricate nature of the brain's neurotransmitter transporters.
Developing new chemical entities
Tactogen's co-founder, Matt Bagget, has dedicated his career to studying MDMA and related compounds. The company's approach includes compiling data on MDMA and related compounds, using machine learning models to predict MDMA-like effects based on compound structures, synthesizing new molecules, and conducting assays to assess their similarity to MDMA. IND enabling studies are conducted to determine safety and toxicology profiles, with the aim of selecting a molecule for human trials. The vision is to develop molecules that retain MDMA's therapeutic effects while addressing its limitations, such as hypertensive effects, diminishing therapeutic outcomes with repeated use, and emotional vulnerability in the days after consumption.
Administering entactogens and potential applications
Traditional MDMA therapy involves intensive preparation, a psychoactive experience with therapist support, and an extended recovery period. However, the potential applications of entactogens extend beyond the classical psychedelic therapy model. Tactogen envisions the possibility of administering these compounds in at-home settings, supporting therapeutic practices like meditation, yoga, and journaling, or as pharmacotherapy for conditions such as alcohol use disorder, PTSD, or social anxiety. While the role of psychotherapy and support remains crucial, the aim is to offer safe and accessible entactogen-based treatments that can be used beyond the traditional therapy setting.
Tactogen's mission and community stakeholder initiative
Tactogen operates as a public benefit corporation, driven by the goal of making healing experiences safer, more effective, and accessible. The company prioritizes involving stakeholders and the broader community, allowing them to concretely participate and become shareholders through initiatives like the community stakeholder initiative. This initiative enables unaccredited investors to invest in the company with a minimum of $100, aiming to expand participation beyond accredited investors and providing opportunities for those who would benefit from these therapies to support and engage with Tactogen's mission.
This episode shares the story of Tactogen, a drug development company making new chemical entities inspired by MDMA. Co-founder Matt Baggott has been fascinated by MDMA and has studied it for 30 years. And while he believes that MDMA can be effective as a therapeutic, his company is developing an MDMA analogue that is designed to be gentler and safer, with the potential to be administered in an at-home setting.