Daniel and Kelly’s Extraordinary Universe

How do parasites evade our immune system? (featuring Dr. John Hawdon)

15 snips
Nov 11, 2025
Join Dr. John Hawdon, a leading parasitologist, as he dives into the intriguing world of parasites like hookworms and malaria. He reveals how these creatures evade our immune systems with clever tactics, such as camouflaging themselves and manipulating host defenses. Hear about the complex life cycles of schistosomes and malaria, the challenges in creating effective vaccines, and the surprising links between sanitation and parasite control. This enlightening conversation sheds light on the hidden battles happening within our bodies.
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INSIGHT

Hookworms Reprogram Host Immunity

  • Hookworms actively secrete molecules that alter host immunity to create a tolerable environment.
  • This immune negotiation produces long-term infections rather than sterile immunity.
ADVICE

Fix Sanitation Before Betting On Vaccines

  • Prioritize sanitation improvements like toilets to break helminth life cycles rather than relying only on vaccines.
  • Consider targeted treatment for high-risk 'wormy' people if broad vaccination isn't cost-effective.
ANECDOTE

The 'Wormy' People Phenomenon

  • Dr. John Hawdon referenced 'wormy people' who repeatedly get heavy infections.
  • He noted genetic or exposure factors likely explain that susceptibility.
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