Modafinil and armodafinil are stimulant meds called “smart meds”. Their use is on the rise, but there are important drug interactions with these meds and certain birth control (BC) options. Additionally, new data has revived attention to the association of the stimulants to congenital birth defects. In this session, we will review the MOA of these meds and discuss BC options with their use. We will also summarize the newly released data showing the association with congenital birth defects.