813 - Is Depression Caused by a Chemical Imbalance?

•Only 30% of patients fully respond to the initial SSRI

•Ultimately less than 55% of people respond to any SSRI.

• WHY???

• SSRIs typically only work on the 5HTIA receptor, but multiple 5HT receptors are involved in mood regulation: 1, 2,

• SSRIs only impact one area of possible dysfunction

• Serotonin creation, secretion, absorption, distribution is impacted by multiple factors.

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