Max Jaderberg, Chief AI Officer at Isomorphic Labs with a background in teaching AI to play games, and Rebecca Paul, Head of Medicinal Drug Design with extensive experience in drug discovery, join the conversation. They delve into how AlphaFold 3 is transforming drug discovery by predicting molecular structures. The discussion covers tackling complex diseases, the challenges of drug efficacy, and the significance of AI in personalizing medicine. They even touch on the ambitious goal of designing treatments for previously deemed "undruggable" diseases.
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AI Revolutionizes Drug Design
AI is transforming drug design into an essential scientific tool, akin to math in science today.
New AI models enable prediction of molecular structures critical for faster drug discovery.
insights INSIGHT
Precision in Molecular Binding
Drugs work by fitting into protein pockets, blocking or modifying their function.
Shape and binding strength are crucial factors for medicine design success.
insights INSIGHT
Navigating Vast Chemical Space
The chemical space of possible drug molecules is astronomical, around 10^60.
AI helps efficiently navigate this vast space using generative models and search strategies.
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In this episode, host Hannah Fry is joined by Max Jaderberg and Rebecca Paul of Isomorphic Labs to explore the future of drug discovery in the age of AI. They discuss how new technology, particularly AlphaFold 3, is revolutionizing the field by predicting the structure of life’s molecules, paving the way for faster and more efficient drug discovery.
They dig into the immense complexities of designing new drugs: How do you find the right molecular key for the right biological lock? How can AI help scientists understand disease better and overcome challenges like drug toxicity? And what about the diseases that are currently considered “undruggable”? Finally, they explore the ultimate impact of this technology, from the future of personalised medicine to the ambitious goal of being able to eventually design treatments for all diseases.
AlphaFold 3 code and weights: https://github.com/google-deepmind/alphafold3
Thanks to everyone who made this possible, including but not limited to:
Presenter: Professor Hannah Fry
Series Producer: Dan Hardoon
Editor: Rami Tzabar
Commissioner & Producer: Emma Yousif
Music composition: Eleni Shaw
Audio engineer: Richard Courtice
Production Manager: Dan Lazard
Studio Manager: Nicholas Duke
Video Director: Bernardo Resende
Video Editor: Bilal Merhi
Audio Engineer: Perry Rogantin
Camera and Lighting Operator: Robert Messere
Production Coordination: Zoey Roberts, Sarah Ellen Morton
Visual Identity and Design: Rob Ashley
Commissioned by Google DeepMind
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