Dr. Joseph Mercola - Take Control of Your Health Metformin Could Lessen Some of the Benefits People Get from Exercise
Dec 29, 2025
Discover how metformin, a common diabetes medication, might dampen the positive effects of exercise. A recent trial showed diminished fitness gains among users. Long-term use of metformin can lead to vitamin B12 deficiency and other risks. Uncover lifestyle factors that disrupt glucose regulation and learn the importance of consistent movement and a nutrient-rich diet. Alternatives like berberine are also discussed. Understanding prevention strategies could outshine medication for diabetes management!
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Metformin Can Dull Exercise Gains
- A 16-week Rutgers trial found metformin blunted exercise gains like aerobic fitness and reduced fasting glucose improvements.
- Metformin reduced training benefits even though some vascular function still improved with exercise.
How Metformin Lowers Blood Sugar
- Metformin lowers blood sugar mainly by reducing liver glucose output and improving insulin sensitivity.
- It is first-line for type 2 diabetes and used off-label for several metabolic conditions.
Monitor B12 And Know Metformin Risks
- Monitor B12 if you've used metformin long-term and supplement 1,000–2,000 mcg orally or use injections for severe deficiency.
- Be aware rare lactic acidosis risk and pause metformin during severe illness or kidney/liver issues.