GasGasGas - The FRCA Primary Exam Podcast GasGasGas - Propofol
Jul 29, 2024
Delve into the fascinating world of propofol, exploring its chemical class and clinical applications. Learn the best strategies for structuring drug answers in exams and understand the intricacies of propofol's pharmacodynamics and potential side effects. Discover the significance of pKa and how it influences drug behavior, plus practical tips for effective patient sedation. The discussion also covers metabolic risks and insights on using propofol in hemodynamically unstable patients. Perfect for anyone looking to enhance their anaesthesia knowledge!
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Structure Your Exam Answer
- Name the drug, class, appearance, additives, concentrations, route and dose when answering exam questions about drugs.
- For propofol state IV dosing ~1–2 mg·kg and note 1% and 2% presentations to avoid errors.
Core Pharmacology And Presentation
- Propofol is a 2,6-phenol derivative presented as a white opaque IV emulsion at 1–2% concentrations.
- It potentiates GABA and causes dose-dependent hypnosis with onset about 30–40 seconds and short bolus offset.
Be Cautious In Hypotension
- Anticipate marked cardiovascular depression: reduced venous tone and systemic vascular resistance lower perfusion pressure.
- Avoid using propofol for induction in haemodynamically unstable awake patients; consider ketamine or titrated alternatives.