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The Intern At Work: Internal Medicine
233. Marrow’s Most Wanted- An Approach to Pancytopenia
Apr 14, 2024
Dr. Laura Habib, a Hematologist-Oncologist, and Dr. Natasha Nathoo, an Internist, discuss the approach to pancytopenia. They cover topics like causes of pancytopenia, comprehensive evaluation, treatment options for Myelodysplastic Syndrome, and the importance of addressing underlying issues for effective management.
11:34
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Quick takeaways
- Pancytopenia can stem from various causes like malignancies, infections, and medications.
- Diagnosis of pancytopenia involves comprehensive assessment, CBC, coagulation studies, and further testing based on suspicion.
Deep dives
Overview of Hematopoiesis and Pancytopenia
Hematopoiesis occurs in the bone marrow, giving rise to various blood cell types like thrombocytes, erythrocytes, and neutrophils. Hematopoietic stem cells differentiate into progenitor cells under the influence of growth factors like EPO, TPO, and GCSF. Pancytopenia, characterized by low levels of hemoglobin, platelets, and white blood cells, can result from diverse underlying issues such as malignancies, infections, immune destruction, nutritional deficiencies, and medications.
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