Emergency Medical Minute
Episode 948: CYP Inducers and Inhibitors
Mar 17, 2025
CYP enzymes play a crucial role in the metabolism of many medications. Discover how CYP inducers can lower drug concentrations, while inhibitors like grapefruit juice can increase them. The podcast delves into real-life implications, particularly for patients on multiple medications. It discusses the risks associated with interactions involving common drugs like Bactrim and Paxlovid, showcasing the need for awareness in polypharmacy. This episode is a must-listen for anyone interested in the nuances of medication management!
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Quick takeaways
- CYP enzymes are crucial for medication metabolism, with inducers reducing and inhibitors increasing drug concentrations, impacting treatment efficacy.
- The recent use of Paxlovid, containing Ritonavir as a CYP inhibitor, highlights the importance of monitoring drug interactions in polypharmacy patients.
Deep dives
Importance of CYP Enzymes in Drug Metabolism
CYP enzymes play a crucial role in the metabolism of approximately 70 to 80% of medications, making it essential to understand their interactions. These enzymes can be inhibited or induced by various substances, leading to significant changes in the efficacy and safety of medications. For example, grapefruit juice is known to inhibit CYP enzymes, while drugs like rifampin can induce them, resulting in altered drug concentrations in the body. An illustrative case highlights a medical student on birth control who, after taking rifampin, experienced an unintended pregnancy due to the reduced effectiveness of her contraceptive method.
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