The Sunday Times tech correspondent Danny Fortson brings on Seth Bannon, founder of venture capital firm Fifty Years, to talk about targeting the truly big problems (1:00), why it took 18 months to raise $5m (2:40), targeting lab-grown meat (6:30), getting the met lobby on their side (8:30), backing birth control (12:00), taking left-field approaches to climate (13:50), taking advantage of the Silicon Valley cultural crisis (17:15), the need for big winners (21:00), the slow death of the Fridman doctrine (26:00), how he started out as a young idealist (28:30), (33:30), when he faked it but didn’t make it (38:20), confessing his sins (41:05), and his worst day of work (42:15).