ICU Primary PrepCast # Epi 62 - ICU Primary Snippet 5- iNO and Prostacyclins
5 snips
Feb 1, 2023 Delve into the mechanisms and adverse effects of inhaled nitric oxide and prostacyclins, exploring their impact on pulmonary circulation, vasodilation, smooth muscle relaxation, and platelet function in detail.
AI Snips
Chapters
Transcript
Episode notes
Pulmonary Vasodilators
- Inhaled nitric oxide (iNO) and prostacyclins are pulmonary vasodilators used in critical care.
- They differ in their mechanisms of action and potential adverse effects.
iNO Mechanism and Effects
- iNO activates guanylate cyclase, increasing cyclic GMP, which leads to smooth muscle relaxation and improved V/Q matching.
- However, it can cause methemoglobinemia, renal impairment, and rebound pulmonary hypertension.
Prostacyclin Mechanism and Effects
- Inhaled prostacyclins activate adenylate cyclase, increasing cyclic AMP, leading to vasodilation.
- Side effects include bleeding, systemic vasodilation, and bronchospasm.