Accelerating ADCs with Mythic Therapeutics' Brian Fiske, Ph.D.
May 27, 2024
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Dr. Brian Fiske of Mythic Therapeutics shares his journey transitioning from academia to biotech industry. They discuss developing ADCs for lung cancer, challenges in funding, and strategic planning. The podcast explores Mythic's unique approach in the ADC space and navigating the competitive biotech industry.
Dr. Brian Fiske's diverse background in science and business fuels Mythic Therapeutics' innovative approach to antibody drug conjugates.
Transitioning seamlessly from academia to industry, Dr. Fiske's entrepreneurial vision propels Mythic Therapeutics' phase one study for non-small cell lung cancer.
Mythic Therapeutics stands out in the competitive ADC landscape by prioritizing patient-centric science and antibody enhancements, setting a new standard in biotech.
Deep dives
Dr. Brian Fisk's Academic and Industrial Overlap
Dr. Brian Fisk seamlessly transitioned from academia to industry with his expertise in cancer metabolism, directly impacting the development and commercialization of two drugs. Focused on antibody drug conjugates, his entrepreneurial decisions are driving Metzik Therapeutics' phase one study for non-small cell lung cancer.
Academic and Professional Background of Dr. Brian Fisk
Dr. Brian Fisk's academic journey spanned from biochemistry to academia, including roles at Bain, MassGen, flagship pioneering, and Agios Pharmaceuticals. With a diverse background in science, business, and lab tech work, his decision to pursue a Ph.D. and entrepreneurial ventures reflects his multidisciplinary approach.
Transition to Industry and Entrepreneurial Insights
Moving from Bain to academia, Dr. Brian Fisk's decision to blend his scientific pursuits with business acumen at flagship pioneering showcases his entrepreneurial vision. Embracing the flexibility and impact of new lab setups, he drew parallels between academia startups, fueling his desire to found Mythic Therapeutics.
Innovation in Antibody Drug Conjugates
Mythic Therapeutics' platform focuses on enhancing antibody drug conjugates' effectiveness by modifying the antibodies to target cancer cells more efficiently. Dr. Brian Fisk's mission is to leverage this innovation to create impact beyond existing treatments, aiming to replace chemotherapy with safer and more effective alternatives.
Future Growth and Clinical Developments at Mythic Therapeutics
Mythic Therapeutics' strategic roadmap involves advancing from phase one clinical trials towards multi-product oncology offerings. The company's innovative approach to antibody engineering and clinical research underpins its goal of building an enduring oncology solution for patients.
Navigating the ADC Landscape and Future Vision
Amidst the competitive ADC landscape, Mythic Therapeutics distinguishes itself by prioritizing patient-centric science and antibody enhancements. Dr. Brian Fisk's focus on tackling challenging patient segments and refining ADC development sets Mythic apart in the evolving and dynamic biotech sector.
Mythic Therapeutics Chief Scientific Officer and co-founder Brian Fiske, Ph.D. broke some unwritten protocol with his rapid and multifaceted transition from academia to industry. He calls his many, and sometimes concurrent, early experiences as an MIT Ph.D. student, a Flagship Ventures Fellow, a Bain consultant, a hospital researcher, and a biopharma consultant indiciative of a young man who didn't want to make decisions. In retrospect, it looks more like the perfect preparatory mix for a guy who's leading a company with a unique approach to a white-hot ADC (antibody-drug conjugate) therapeutics market. On this epsiode of the Business of Biotech, get to know Brian as we peel back the layers to expose what's fueling the rapid rise of Mythic's ADC candidate in non-small cell lung cancer.
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