Radiolab

Memory and Forgetting

Jun 7, 2007
Join neuroscientist Joseph LeDoux, a leading expert on emotion and memory, as he delves into the intriguing world of how memories are formed and erased. Discover the surprising role proteins play in memory formation and the potential to disrupt recalled memories through drugs. LeDoux also discusses the artistic representation of memories, exploring how our recollections are reconstructed over time. Plus, hear about Clive Wearing, a man with severe amnesia who showcases the resilience of emotional memory, revealing how love and music can tether us to our identities.
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INSIGHT

Memory Is Reconstructive, Not Static

  • Memory is not a static filing cabinet or hard drive but a creative, reconstructive process.
  • Every act of remembering rebuilds the memory and subtly changes it.
INSIGHT

Proteins Build Memories

  • Forming long-term memories requires new protein synthesis and cellular changes linking neurons.
  • Block those proteins (with anisomycin) during formation and the memory fails to form.
INSIGHT

Recalling Makes Memories Vulnerable

  • Reactivating a memory returns it to an unstable state that can be altered or erased.
  • Administering protein-blocking drugs during recall can remove an already formed memory.
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