The Most Asked HRT Questions of 2025 — Answered by Karen (a.k.a. The Ones She Hears 10,000 Times a Year)

Nov 22, 2025

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Curious about the future of hormone replacement therapy (HRT) and its impact on menopause? This episode features my answers to the most common HRT questions of 2025. Can HRT be your secret weapon for a healthier, longer life, even if you aren't experiencing typical menopause symptoms?

Is HRT the missing piece in your weight loss journey? Explore the fascinating link between hormone cycling and midlife wellness. What does the latest research say about personalized hormone approaches, and how might these strategies keep cardiovascular disease and osteoporosis at bay?

Ever wondered about the mysteries of hormone metabolism? We'll unpack tests like the Dutch test and their role in optimizing HRT dosage. Can progesterone and estrogen improve your sleep, mood, and even joint health? Get ready to uncover the benefits of HRT beyond menopause!

In this episode, we uncover the answers to:

1. If I have no symptoms, should I still take HRT?
2. It's natural to go into menopause — so why would I use HRT?
3. I'm using vaginal estrogen… why am I still dry?
4. Is oral bioidentical estradiol safe?
5. Will HRT help me lose weight?
6. Do I have to cycle my hormones?
7. Can I start HRT if it's been more than 10 years since menopause?
8. Can I start HRT even if I'm still cycling but have symptoms?
9. I get bloated or gain weight on estrogen — does that mean it's not right for me?
10. My period came back after starting HRT — is that normal?
11. Is my estradiol dose high enough?
12. Do I have to stay on HRT forever?
13. What's the difference between estradiol and estriol — and do I need both?
14. Should I take progesterone if I don't have a uterus?
15. Can HRT help my sleep?
16. Can HRT help my libido?
17. Is spotting normal on HRT?
18. What are your thoughts on pellets?
19. Why do my estrogen levels still look "low" on blood work even while on HRT?
20. Can HRT help with joint pain and inflammation?

Listen now to discover how HRT can revolutionize your midlife health journey. Don't miss this Q&A episode filled with insights and expert advice to empower your health decisions!