The Internet Book of Critical Care Podcast IBCC Episode 115 - Invasive Candidiasis
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Jun 29, 2021 This podcast covers the diagnosis and treatment options for invasive candidiasis, including the importance of blood cultures and beta-D-glucan. It also discusses the necessity of echo cardiograms and dilated eye exams in Candidemia, as well as the therapy for antifungals in invasive candidiasis.
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Colonization vs. Invasive Infection
- Patients in the ICU become colonized with Candida due to broad-spectrum antibiotics destroying their microbiome.
- Most Candida positive cultures represent colonization, not invasive infection requiring treatment.
Remove Lines with Candidemia
- Always remove central lines when blood cultures grow Candida.
- Treat any candidemia seriously; it is not just colonization.
Shift Away from Empiric Antifungals
- Early or preemptive antifungal therapy for Candida has not shown benefit in clinical trials.
- The trend is moving away from empirical antifungal treatment towards selective use.