Futureproof with Jonathan McCrea How blood vessels boost lab-grown mini-brains
Jan 11, 2026
Dr. Mihai Lomora, a scientist at CÚRAM, discusses the groundbreaking use of vascularisation in lab-grown brain tissues, enhancing their longevity and functionality. Dr. Jessamyn Fairfield brings insight into reducing aviation emissions and the role of efficient aircraft designs. Dr. Fergus McAuliffe dives into the fascinating world of migrions and their viral transport capabilities. Together, they explore the ethical implications of organoid research and the potential to replace animal models, opening new avenues for neuroscience.
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Mini-Brains Are Purposeful Models
- Cerebral organoids are lab-grown, small clumps of brain-like tissue that resemble but do not replicate a full human brain.
- They offer species-relevant models that could replace some animal studies and improve human-focused drug testing.
Use Organoids To Replace Animal Models
- Use cerebral organoids to bridge gaps where animal models poorly reflect human brain biology.
- Develop more complex organoid systems to study slow neurodegenerative diseases like Alzheimer’s and Parkinson’s.
Vessels Fix Organoid Lifespan Limits
- Lack of internal blood supply makes organoid cores starve and die, limiting longevity and disease modelling timeframes.
- Introducing vasculature lets nutrients and oxygen reach the core and extends culture lifespan for long-term studies.