Kasper Roet, Ph.D., is the founder and CEO of QurAlis, a biotech innovator focused on genetic medicines for ALS. In this fascinating conversation, he discusses his journey from the Dutch Brain Bank to leading a consortium aimed at reforming the conservative FDA regulations that are driving clinical trials offshore. Roet emphasizes the critical need for a flexible approach to expedite therapy approvals and shares insights on the advancements in genetic medicine since the first ALS gene was discovered.
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question_answer ANECDOTE
From IT to Biotech
Kasper Roet started his career in IT during the internet boom, building computers and networks.
His passion for biology led him back to school for medical biology and neuroscience, pursuing gene therapy.
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Early Computers
Roet's first computer was a Commodore 64, preceded by an Atari game console.
He enjoyed taking them apart and trying to improve their performance for better gaming.
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Dutch Brain Bank Experience
Roet's experience at the Dutch Brain Bank provided hands-on experience with brain tissue and autopsies.
This experience highlighted the frequent misdiagnosis of patients based on clinical symptoms alone.
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Dr. Kasper Roet's hands-on work at the Dutch Brain Bank informed his leadership at the biotech QurAlis, where three clinical programs targeting specific genetic mechanisms in ALS are now underway. On this episode of the Business of Biotech, Life Science Leader's Ben Comer joins to co-host a conversation with Dr. Roet that goes deep on his company's genetic medicine approach to ALS, and even deeper into his opinions on, and growing influence over, the regulatory environment. Roet says that as the FDA's conservative approach to genetic medicines has pushed clinical trials overseas, he's been inspired to form and lead a consortium of 11-and-growing biotechs seeking regulatory reform through organized meetings and lobbying efforts. Join us for this latest of our BoB@JPM series from San Francisco.
The 2025 BoB@JPM series is supported by Alston & Bird, whose national health care and life sciences practice has more than 100 attorneys actively involved and integrated across the full spectrum of legal disciplines including regulatory, compliance, public policy, transactional, corporate governance, securities, FDA, biotechnology, intellectual property, government investigations, and litigation practice areas. Learn more at www.alston.com.
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