Raising Health cover image

Raising Health

Harnessing Water Dynamics for Drug Design with Michael Crackower and Jason Burch

Aug 20, 2024
Michael Crackower, Chief Scientific Officer at Ventus Therapeutics, and PhD researcher Jason Burch dive into the future of drug discovery. They unveil the ReSOLVE platform, designed to quickly iterate small molecular compounds for therapeutic use. The duo discusses the importance of water dynamics in protein interactions, machine learning's role in drug design, and their strides in targeting NLRP3 for neurodegenerative diseases. With groundbreaking data and a push to enter clinical trials, they highlight the rapid progress made from concept to investigational new drug.
37:24

Podcast summary created with Snipd AI

Quick takeaways

  • Ventus Therapeutics' ReSOLVE platform revolutionizes drug design by treating water as a dynamic entity for better molecular interactions.
  • The company's strategic focus on the innate immune system opens doors to innovative therapies for aging-related and mitochondrial dysfunction diseases.

Deep dives

Innovations in Drug Discovery

Ventus Therapeutics focuses on leveraging the Resolve platform to transform drug discovery processes, particularly concerning small molecules. This platform enables more precise design and iteration of small molecular compounds for therapeutic use, aiming to increase the efficiency and speed of getting drugs into clinical testing. For instance, they discussed transitioning from initial drug candidates to Investigational New Drug (IND) status in record time, having achieved three such transitions within a single year, which is rare in the pharmaceutical industry. This approach marks a significant advancement from traditional methods, highlighting the potential of small molecules in addressing unmet health needs.

Get the Snipd
podcast app

Unlock the knowledge in podcasts with the podcast player of the future.
App store bannerPlay store banner

AI-powered
podcast player

Listen to all your favourite podcasts with AI-powered features

Discover
highlights

Listen to the best highlights from the podcasts you love and dive into the full episode

Save any
moment

Hear something you like? Tap your headphones to save it with AI-generated key takeaways

Share
& Export

Send highlights to Twitter, WhatsApp or export them to Notion, Readwise & more

AI-powered
podcast player

Listen to all your favourite podcasts with AI-powered features

Discover
highlights

Listen to the best highlights from the podcasts you love and dive into the full episode