It's all about Conduction: Calcium's Role in Hyperkalemia​

Revising the Understanding of Calcium in Hyperkalemia

The traditional view of calcium's role in treating hyperkalemia is challenged by recent findings, suggesting that its beneficial effects are not due to membrane stabilization but rather normalization of cardiac conduction velocity. In a laboratory study involving dog myocytes, it was demonstrated that calcium did not restore action potential duration or affect the resting membrane potential, but instead improved cardiac conduction velocity. This revelation implies that the application of calcium treatment should be considered primarily in cases where EKG shows slowed conduction, specifically with signs like QRS prolongation or bradycardia, rather than in situations of isolated peaked T waves. This shift in understanding could significantly influence clinical approaches to treating hyperkalemia and necessitates reevaluation of long-standing medical teachings.