The R vs. S Enigma: Ketamine Enantiomers and Their Distinct Actions

We dive into the latest research on ketamine's therapeutic potential, including its role in treating ischemic stroke, postoperative cognitive dysfunction (POCD), and PTSD. You'll hear how scientists are studying its effects on brain regions like the hippocampus and amygdala, as well as its impact on neuroinflammation, fear memory, and neurogenesis.

 

We'll also explore ketamine’s use in anesthesia, its interactions with drugs like oral morphine, and how it's monitored using tools like EEG. From molecular techniques like RT-qPCR and Western blotting to real-world applications—this episode breaks down the science driving ketamine's future in medicine.

 

Here’s some of what you’ll hear in this episode:

🧠 Ketamine’s impact on brain function, cognition, and EEG readings
🧬 NMDA receptors, BDNF, cytokines & other molecular targets
📉 How ketamine may raise delirium risk in cognitively impaired patients
🧪 In vitro studies on ketamine’s anti-inflammatory and anticancer potential
📊 Why EEG interpretation—not just BIS numbers—matters for patient safety

 

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