Trialing treatments for Long Covid, and a new organelle appears on the scene
Apr 11, 2024
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Clinicians and researchers discuss trials for Long Covid treatments, including HIV drugs and monoclonal antibodies. A symbiosis expert introduces the new organelle called nitroplast. They explore the benefits of having nitrogen-fixing organelles in cells and the challenges of studying and treating Long Covid
Researchers are actively testing drugs and antibodies against long COVID to address the root causes of the syndrome.
Researchers are exploring theories like viral persistence and immune dysfunction to find effective treatments for long COVID.
Deep dives
Long COVID Trials and Treatments
Researchers are actively testing drugs and antibodies against long COVID, aiming to address the root causes of the syndrome rather than just its symptoms. With a lack of proven treatments currently available, individuals like Shelley Hayden have turned to self-experimentation with supplements and off-label medications in the absence of approved options. Trials are investigating various approaches, including viral persistence theories, to find effective treatments for long COVID.
Understanding Long COVID's Biological Mechanisms
Researchers are exploring different theories regarding the underlying causes of long COVID, including viral persistence and immune system dysfunction. There is a focus on clearing viral remnants within the body, leading to debilitating symptoms. Trials are open to participants without detectable virus levels, emphasizing the complexity of diagnosing and treating the condition.
Challenges in Measuring Treatment Success
Clinical trials for long COVID treatments face difficulties in measuring success, as traditional biomarkers are insufficiently capturing the condition's complexities. While symptoms are a primary focus for monitoring, researchers are also analyzing immune cell responses and blood markers to gauge treatment efficacy. The lack of standardized objective measures poses a challenge in evaluating the effectiveness of potential treatments.
Emerging Approaches in Long COVID Treatment
Trials are exploring diverse treatment strategies for long COVID, including testing drugs like Paxlovid and antivirals used in HIV treatment. Monoclonal antibodies are also being investigated as potential solutions to neutralize lingering virus remnants. Researchers are hopeful that these trials will yield insights into personalized treatments and help address the urgent need for effective long COVID therapies.
]Researchers are testing HIV drugs and monoclonal antibodies against long-lasting COVID-19, and what it takes to turn a symbiotic friend into an organelle
First up on the show this week, clinical trials of new and old treatments for Long Covid. Producer Meagan Cantwell is joined by Staff Writer Jennifer Couzin-Frankel and some of her sources to discuss the difficulties of studying and treating this debilitating disease.
Next: Move over mitochondria, a new organelle called the nitroplast is here. Host Sarah Crespi talks with Tyler Coale, a postdoctoral scholar in the University of California, Santa Cruz’s Ocean Sciences Department, about what exactly makes an organelle an organelle and why it would be nice to have inhouse nitrogen fixing in your cells.
This week’s episode was produced with help from Podigy.