How do you spot opportunities hidden in plain sight? In this episode, our host, Annie Duke, sits down with Lux Capital co-founder Josh Wolfe to explore his unconventional approach to venture investing and decision-making under uncertainty. From his early days in Coney Island to building a multibillion-dollar fund, Josh shares how he spots hidden opportunities by asking a simple but powerful question: “What sucks?” He explains how this mindset drives Lux’s strategy of investing where others aren’t looking, taking bold bets on frontier technologies, and uncovering breakthroughs before they hit the mainstream. Together, Annie and Josh unpack the psychology behind big bets—balancing optimism with skepticism, managing uncertainty, avoiding biases, and learning when to trust your gut versus the data.

Key takeaways include how to distinguish between “nice-to-have” vs. “must-solve” problems, how to leverage inside vs. outside views for better decision-making, and why understanding human nature is as critical as understanding technology when investing in the future.

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