Listener feedback on sports “disqualification,” big digoxin news, Brugada syndrome, another positive finerenone study, and unblinded transcatheter trials are discussed by John Mandrola, MD, in this week's podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

https://www.medscape.com/twic

I Listener Feedback

JACC EP Paper https://www.jacc.org/doi/10.1016/j.jacep.2025.03.013

II Digoxin News

DIGIT HF Baseline Characteristics paper https://doi.org/10.1002/ejhf.3679
DIGIT HF Rationale paper https://pmc.ncbi.nlm.nih.gov/articles/PMC6607489/
Dig trial https://www.nejm.org/doi/full/10.1056/NEJM199702203360801
DECISION trial https://onlinelibrary.wiley.com/doi/full/10.1002/ejhf.3428
Ziff et al BMJ meta-analysis https://www.bmj.com/content/351/bmj.h4451

III Brugada Syndrome

Gomes et al https://doi.org/10.1093/europace/euaf091

IV Another Finerenone Substudy Published

FINEARTS-HF trial substudy, Bhatt, A et al https://doi.org/10.1016/j.cardfail.2025.05.006
FINEARTS HF Main paper https://www.nejm.org/doi/full/10.1056/NEJMoa2407107
TOPCAT https://www.nejm.org/doi/full/10.1056/NEJMoa1313731
TOPCAT regional variation Circ paper https://www.ahajournals.org/doi/10.1161/circulationaha.114.013255

V Another Opinion on Unblinded Transcatheter Intervention Trials

Kaul https://eurointervention.pcronline.com/article/unblinded-trials-of-transcatheter-interventions-with-subjective-endpoints-what-are-the-implications

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Questions or feedback, please contact news@medscape.net

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