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In this podcast episode, the hosts discuss the United States Preventive Services Task Force's updated recommendation on pre-exposure prophylaxis (PrEP) for HIV prevention. They interview Dr. John B. Wong, a member of the task force, who highlights the importance of PrEP in reducing HIV transmission. The discussion covers the different forms of PrEP, including oral medications (TDFFTC and TAFFTC) and the injectable form (cabotegravir). The hosts emphasize the need for regular HIV and STI testing, as well as ongoing monitoring of renal function. They also address the importance of a non-judgmental approach when discussing sexual history and risk factors with patients. The episode concludes with resources provided by the CDC and the task force for further information on PrEP.