063CE: Anti-CD47 Testing Interference with Connie Westhoff

Feb 6, 2019

Connie Westhoff, researcher studying anti-CD47, discusses the interference this drug causes in blood bank testing. They explore the challenges in removing CD-47, the interference in ABO and antibody screening, and the use of polyethylene glycol absorption to remove interference. The importance of pretreatment ABO and RH typing, genotyping, and antigen match units are highlighted. The effects of anti-CD38 and potential interfering antibodies are also discussed.

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Introduction

00:00 • 4min

The Role of CD-47 in Red Blood Cell Testing

04:27 • 11min

Interference of Drug in ABO and Antibody Screening

15:38 • 15min

30:47 • 2min

Testing Interference with Polyethylene Glycol Absorption

32:17 • 2min

Achievable Outcomes with Anti-CD-47 Interference and Importance of Pretreatment ABO and RH Typing

33:48 • 2min

The Importance of Genotyping and Antigen Match Units

35:49 • 2min

Comparison of Anti-CD38 and Anti-CD47 on Red Blood Cells

37:33 • 12min