Hosts discuss a patient's presentation in the ED, while introducing their other podcast. They cover adrenal insufficiency, its causes, and diagnosis. They emphasize the importance of recognizing adrenal crisis symptoms and electrolyte abnormalities. Managing adrenal crisis and appropriate dosage of hydrocortisone are also discussed.
Adrenal insufficiency can be caused by autoimmune Addison's disease, hypothalamic or pituitary impairment, or abrupt cessation of chronic steroid use.
Prompt recognition and treatment of adrenal crisis is vital, including stress dose steroids and addressing the underlying cause.
Deep dives
The Case: A 25-Year-Old Male with Vomiting and Fatigue
A 25-year-old male presents to the emergency department with complaints of vomiting and fatigue. Over the past three days, his symptoms have worsened, and he has also noticed increased urine output. He mentions that he has been urinating into a gallon milk jug to minimize flushing. He identifies himself as a "Renney" who travels with the Renaissance fair. He admits to not filling his prescriptions since leaving home, including steroids for his kidney problems. Given his presentation, hyponatremia is expected.
Understanding Adrenal Insufficiency
Adrenal insufficiency, also known as Addison's disease, is discussed as the likely diagnosis in the presented case. Adrenal insufficiency can be primary, secondary, or tertiary, and is often seen in patients on chronic steroid therapy. Primary adrenal insufficiency is most commonly caused by autoimmune Addison's disease, while secondary adrenal insufficiency can result from hypothalamic or pituitary impairment. Tertiary adrenal insufficiency occurs due to abrupt cessation of chronic steroid use. The diagnosis of adrenal insufficiency typically requires an ACTH stimulation test, although low random cortisol levels can indicate a probable diagnosis. Hyperpigmentation, especially in sun-exposed areas, is a common finding in Addison's disease.
Management of Adrenal Crisis
Adrenal crisis is the most relevant scenario for emergency physicians. Prompt recognition is crucial when hypotension is unresponsive to standard therapies. Patients experiencing adrenal crisis typically require stress dose steroids, such as hydrocortisone 100 mg IV, in addition to treatment of the underlying cause of the crisis. Adrenal insufficiency patients not in crisis should receive electrolyte correction and admission as they are prone to develop crises under physiological stressors. Fingerstick glucose checks should be done frequently, and depending on the severity, patients may require continuous IV dextrose. Increasing steroid doses during stressful situations is important to prevent adrenal crisis.
We're going "full nerd" into the secret scene of renaissance fairs... and you thought carnivals were bad. Let's cover a rare condition that's more common than you think!
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Cite this podcast as: Briggs, Blake; Wosiski-Kuhn, Marlena 197. Adrenal Crisis...at the Renaissance Fair. October 23th, 2023. Accessed [date].
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