Mind & Matter Inflammation, Innate Immunity, Allergies & Allergens, Immune System Evolution, Fasting & Metabolism | Clare Bryant | 144
Mar 10, 2024
Topics discussed include mechanisms of inflammation, innate vs. adaptive immunity, chronic inflammation, allergies & allergens, evolution of the immune system, anti-inflammatory effects of fasting. Dr. Claire Bryant explores the intricate dance of the immune system, role of inflammasomes, chronic inflammation, allergens, pathogens, immune responses, and metabolic regulation through fasting & fatty acids.
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Innate Immunity's Dual Detection Role
- Innate immunity rapidly detects pathogens through pattern recognition receptors recognizing molecular patterns unique to microbes.
- These receptors also detect misplaced host molecules, linking innate immunity to chronic inflammatory diseases.
Innate Immunity Evolves With Lifestyle
- Innate immune receptors are ancient and vary widely across species based on lifestyle and diet.
- Species like carnivores may lose some receptors due to different pathogen exposure and antimicrobial peptides in their diet.
Innate to Adaptive Immune Link
- Innate immune cells detect pathogens, attempt to engulf and destroy them, then present antigens to activate adaptive immunity.
- Adaptive immune cells then proliferate to specifically target and clear the infection with memory formation.