Neurology Minute

Estrogen Exposure from Modern Hormonal Contraceptives and Vascular Risk in Women with Migraine: A Nationwide Electronic Health Record Database Study

Apr 16, 2025
Discover the intriguing relationship between hormonal contraceptives and vascular risks in women who suffer from migraines. A recent study shows no major differences in vascular health between users and non-users of estrogen-containing contraceptives. However, it sheds light on an increased stroke risk for non-user women experiencing migraine with aura. Tune in to unpack these findings and their implications for women's health!
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INSIGHT

Low-Dose Estrogen Contraceptives Safe

  • Combined hormonal contraceptives with low-dose estrogen do not increase vascular risk in women with migraine.
  • Migraine with aura raises vascular risk only among women not using these contraceptives.
INSIGHT

Aura Increases Stroke Risk

  • Women with migraine with aura have a higher incidence of ischemic stroke when not using hormonal contraceptives.
  • This risk difference is less clear among users of combined hormonal contraceptives.
ADVICE

Follow Headache Society Guidelines

  • Clinicians can safely follow International Headache Society guidelines to prescribe combined hormonal contraceptives in women with migraine.
  • This applies to women both with and without aura, reflecting current clinical practice evidence.
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