The Stem Cell Podcast

Ep. 190: “Immunology and Podcasts” Featuring Drs. Brenda Raud and Jason Goldsmith

Apr 6, 2021
Dr. Brenda Raud, a postdoctoral researcher focusing on T cell immunology, and Dr. Jason Goldsmith, a physician-scientist specializing in gut immunity, discuss their new Immunology Podcast. They delve into T-cell therapies for solid tumors, the impact of the microbiome on immunity and cancer treatment, and the importance of diet and obesity in immune health. They also share how COVID-19 has changed public perceptions of immunology and their motivation for launching the podcast to simplify complex research for a broader audience.
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INSIGHT

Minimal Synthetic Cells Reveal Hidden Biology

  • Synthetic minimal cells can be engineered by iterative gene deletions and selective add-backs to restore division.
  • Only two of seven genes needed for division were previously linked to cell division, revealing many unknowns.
INSIGHT

CRISPR Enables Muscle Chimerism In Pigs

  • CRISPR-created pig embryos lacking myogenic regulators can be complemented with donor cells to form muscle.
  • Early human iPSC contributions produced humanized skeletal muscle in pig embryos, showing proof-of-concept for organ chimerism.
INSIGHT

Engineered iPSC Model Recreates Outer Retinal Barrier

  • iPSC-derived co-cultures of RPE, endothelial, and mesenchymal cells recreate the outer blood-retinal barrier architecture.
  • RPE and mesenchymal secreted factors drive choriocapillaris fenestration and implicate FGF/MMP signaling in AMD.
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