Progress, Potential, and Possibilities Podcast / Show Dr. Peter Fedichev, PhD - CEO, Gero - Hacking Complex Diseases & Aging with AI & Digital Biomarkers
Oct 26, 2022
Dr. Peter Fedichev, PhD, is the CEO of Gero, where he employs AI and digital biomarkers to tackle aging and complex diseases. He discusses his transition from physics to biotech, highlighting the importance of resilience in aging through longitudinal data. Peter introduces the concept of thermodynamic biological age and examines unique insights from naked mole-rats. He emphasizes the power of AI in drug repurposing and shares Gero's ambitious plans for enhancing the human healthspan, inviting collaboration on groundbreaking scientific advancements.
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Find The Exponential Driver Of Aging
- Aging in populations shows exponential mortality increase (doubling ~8 years) that must be explained by an underlying exponential driver.
- To control lifespan you must identify the parameter that drives that exponential instability, not just linear biomarkers.
Resilience Is A Dynamic Limit On Lifespan
- Longitudinal data reveals resilience as a dynamic property: recovery time from perturbations lengthens with age.
- Resilience can decline to zero at extreme ages, setting a limit on maximum human lifespan.
Why Mouse Rejuvenation Often Fails In Humans
- Humans are dynamically stable for decades, so transient reductions of damage (e.g., rapamycin) often produce only temporary benefits.
- Drugs that target damage hallmarks may mainly help late-life, when resilience collapses into exponential disintegration.