CHIP & CCUS: knowledge gaps, ongoing trials & recommendations for approaching patients with myeloid precursors
Mar 28, 2024
auto_awesome
Experts Uma Borate, Kelly Bolton, and Eric Padron discuss the early stages of blood disorders, CHIP, and CCUS, emphasizing the importance of multidisciplinary teamwork. They cover topics such as blood cancer risk assessment, diagnostic challenges, bone marrow biopsies, and the connection between clonal hematopoiesis patients and cardiovascular diseases.
Early identification of CHIP and CCUS can assist in preventing progression to more serious hematologic malignancies like leukemia or MDS.
Multidisciplinary teamwork is essential in managing CHIP and CCUS, emphasizing the need for collaboration across specialties to address associated health risks.
Deep dives
Understanding Clonal Hematopoiesis and Potential Interventions
Experts in the podcast discuss the concept of clonal hematopoiesis, emphasizing the need for further research beyond the initial identification of this precursor state. They highlight the importance of monitoring and intervening in ways that minimize harm to patients and prevent disease progression. Ongoing trials targeting high-risk populations such as those with clonal cytopenia of undetermined significance (CCUS) show promise in early interventions to prevent hematocrit progression.
Diagnostic Recommendations for Clonal Hematopoiesis and CCUS
Recommendations are made for healthcare professionals, especially oncologists in the community, to refer patients with cytopenias and unclear diagnoses to specialized centers for accurate identification of conditions like CCUS. Emphasizing the significance of distinguishing between CCUS and myelodysplastic syndrome, the importance of bone marrow biopsies for precise diagnosis is highlighted.
Addressing Health Risks Associated with Clonal Hematopoiesis
The podcast concludes by discussing the interdisciplinary approach required for managing clonal hematopoiesis, particularly in addressing health risks like cardiovascular diseases. Highlighting the need for collaboration with specialists in related fields, the experts stress the importance of risk modification strategies for associated conditions alongside standard healthcare practices for overall patient well-being.
Clonal hematopoiesis of indeterminate potential (CHIP) and clonal cytopenia of unknown significance (CCUS) are considered precursor diseases to hematologic malignancies, indicating early stages of blood disorders that may progress to more serious conditions such as leukemia or myelodysplastic syndromes (MDS).
In this podcast, Uma Borate, MD, The Ohio State University, Columbus, OH, Kelly Bolton, MD, PhD, Washington University School of Medicine, St. Louis, MO, and Eric Padron, MD, Moffitt Cancer Center, Tampa, FL, discuss knowledge gaps in the field, share insights from ongoing trials, and further emphasize the importance of multidisciplinary teamwork in managing CHIP and CCUS. This episode is part of our podcast series from the 2024 Intercepting Blood Cancers (IBC) Workshop, which was held in Lisbon, Portugal.