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VJHemOnc Podcast

CHIP & CCUS: knowledge gaps, ongoing trials & recommendations for approaching patients with myeloid precursors

Mar 28, 2024
Experts Uma Borate, Kelly Bolton, and Eric Padron discuss the early stages of blood disorders, CHIP, and CCUS, emphasizing the importance of multidisciplinary teamwork. They cover topics such as blood cancer risk assessment, diagnostic challenges, bone marrow biopsies, and the connection between clonal hematopoiesis patients and cardiovascular diseases.
13:02

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Quick takeaways

  • Early identification of CHIP and CCUS can assist in preventing progression to more serious hematologic malignancies like leukemia or MDS.
  • Multidisciplinary teamwork is essential in managing CHIP and CCUS, emphasizing the need for collaboration across specialties to address associated health risks.

Deep dives

Understanding Clonal Hematopoiesis and Potential Interventions

Experts in the podcast discuss the concept of clonal hematopoiesis, emphasizing the need for further research beyond the initial identification of this precursor state. They highlight the importance of monitoring and intervening in ways that minimize harm to patients and prevent disease progression. Ongoing trials targeting high-risk populations such as those with clonal cytopenia of undetermined significance (CCUS) show promise in early interventions to prevent hematocrit progression.

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