Neuroscientist Gül Dölen explores how psychedelics paired with mindful integration can reopen the brain’s sensitive learning windows to rewire habits, heal trauma, and expand consciousness.

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In this episode of Mindrolling, Gül and Raghu chat about:

Gül’s research on psychedelics and how we can translate animal studies into human neuroscience
Looking to Octopuses for sociological answers using MDMA
Critical periods—windows when the brain is most open to learning and environmental influence.
Psychedelics as the master key to reopening critical periods, especially when paired with therapy
Inducing metaplasticity with psychedelics, reshaping harmful patterns, and promoting transformation.
Non-substance methods to reopen critical periods, like sensory and social deprivation
How mystical practices such as meditation and silent retreats can trigger a “beginner’s mind” state for deep insights
How psychedelics propose a learning model rather than a biochemical imbalance model towards approaching depression, addiction, or PTSD
Focusing on post-trip integration to harness long-term benefits from the psychedelic experience
Maximize the integration period to cement insights gained during psychedelic journeys
The social and psychological changes we go through as we age and adapt to new environments/situations
The importance of “set and setting” and how it can influence psychedelic experiences and the formation of helpful or harmful habits

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About Gül Dölen:

Dr. Gül Dölen is a Professor and the Bob & Renee Parsons Endowed Chair in the Department of Neuroscience, and Department of Psychology, the Berkeley Center for the Science of Psychedelics and the Helen Wills Neuroscience Institute at the University of California, Berkeley. Dr Dölen also maintains an Adjunct Professorship in Neuroscience and Neurology at the Johns Hopkins University, School of Medicine. Dr. Dölen researches the role psychedelics may have in unlocking critical periods in Dölen Lab. She is the recipient of several prestigious awards.

“It turns out that our results really suggest that psychedelics are those master keys that we have been looking for all this time.” – Gül Dölen

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How is the immune reconstitution in patients who stop therapy after achieving MRD negativity?