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How is the immune reconstitution in patients who stop therapy after achieving MRD negativity?
Feb 9, 2023
Discover how immune reconstitution is studied in patients who stop therapy after achieving MRD negativity. Hear about markers for humoral immune recovery, infection rates, and potential implications for future studies.
03:10
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Quick takeaways
- Patients who stop therapy post-MRD negativity show robust immune reconstitution post-stem cell transplant.
- Immune reconstitution post-treatment cessation crucial in preventing infections and improving patient outcomes.
Deep dives
Humeral and Immune Reconstitution Analysis After Treatment Cessation
Patients achieving MRD negativity in the Master's study who were able to discontinue treatment after two consecutive MRD negative assessments showed robust immune reconstitution following stem cell transplant. Patients who received Dara KRD consolidation had decreased humeral immunity initially but eventually recovered their immune repertoire after treatment cessation. Although gamma globulins did not return to pre-treatment levels, infection rates remained low, implying successful immune reconstitution post-therapy.
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