Razib Khan's Unsupervised Learning

Antonio Regalado: CRISPR babies 6 years later

16 snips
Feb 27, 2025
Antonio Regalado, a seasoned reporter from MIT Technology Review, dives into the profound consequences of the CRISPR baby scandal. He reveals how He Jiankui, the scientist behind the genetic modifications, has shifted his focus to social media, raising new questions about ethics in gene editing. Regalado discusses the rise and fall of CRISPR biotech startups, the gray market emerging for genomic services, and the future implications of genetic interventions on society. The episode critically examines the balance between scientific innovation and ethical responsibility in genetic technology.
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ANECDOTE

First Whole Genome Sequenced Baby

  • Antonio Regalado broke the story about Razib Khan’s son's in utero whole genome sequencing.
  • This was believed to be the first documented case of a healthy person born with their genome sequenced.
INSIGHT

CRISPR Democratizes Gene Editing

  • CRISPR democratized gene editing, making it cheap, easy, and specific.
  • It transitioned genetic engineering from niche applications to widespread potential, sparking excitement and fear.
INSIGHT

CRISPR Enables Embryo Editing

  • CRISPR's efficiency allows gene editing of single cells like embryos, a feat previously impossible with older methods.
  • This breakthrough has revolutionized genetic engineering, particularly for animals, but also raises ethical concerns for humans.
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