Inner Cosmos with David Eagleman Ep 97 "Can we rewrite the human code?" (with Trevor Martin)
Mar 24, 2025
In this engaging conversation, Trevor Martin, co-founder and CEO of Mammoth Biosciences, discusses groundbreaking CRISPR technologies and their capacity to rewrite our genetic code. He explores ethical dilemmas surrounding genetic modifications, emphasizing their potential to reshape human identity and health. From the implications for disease treatment to issues of access and equity, Trevor highlights how advancements in gene editing may influence our future. This thought-provoking dialogue encourages listeners to reflect on the societal impact of altering our biological legacy.
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CRISPR's Natural Origins
- CRISPR technology, used for gene editing, originates from bacteria's natural defense mechanisms against viruses.
- Nature uses CRISPR systems for protection, similar to our adaptive immune systems.
CRISPR's Memory Function
- Bacteria use CRISPR's memory function to recognize and defend against previously encountered viruses.
- This "memory" is the origin of CRISPR's name: Clustered Regulatory Interspace Short Palindromic Repeats.
Size and Delivery
- Delivering CRISPR systems to target cells is challenging due to the large size of Cas9 proteins.
- Smaller CRISPR systems, like nanoCas, enable delivery throughout the body using methods like adeno-associated viruses (AAV).