

JAMA Neurology : β-Blocker Use and Delayed Onset and Progression of Huntington Disease
9 snips Dec 2, 2024
In this installment, Jordan L. Schultz, an Assistant Professor of Neurology and Psychiatry at the University of Iowa, discusses his research on β-blockers and their role in Huntington's disease. Schultz highlights how these medications might delay the disease's onset and progression. He explores findings showing that patients on β-blockers enjoy better clinical outcomes and lower motor diagnosis risks. The conversation also delves into the use of different types of β-blockers and their potential impact on psychiatric symptoms, calling for further research.
AI Snips
Chapters
Transcript
Episode notes
Huntington's Disease and Autonomic Imbalance
- Huntington's Disease progressively affects motor skills, cognition, and mental health.
- Current treatments focus on lowering the mutant Huntington protein, but new research explores the role of autonomic imbalance.
Beta Blocker Use in Huntington's Disease
- Beta blockers are typically used for cardiovascular issues in Huntington's Disease patients.
- They could potentially treat some HD symptoms but are not yet a standard practice.
Study Methodology
- The Enroll-HD study analyzed beta blocker use in pre-manifest and motor-manifest HD patients.
- Using propensity score matching, researchers compared treated and untreated groups to assess disease progression.