EP101 - ADHD Medication & Violence.

ADHD MEDICATION & VIOLENCE is an episode designed to make parents aware of the dangerous effects of stimulant drugs for ADHD. In 2006, the FDA’s ADHD psychiatric review team called for stronger warnings on ADHD drugs after a safety review found almost 1,000 case reports of psychosis (including hallucinations) or mania related to Adderall, Concerta, Ritalin and Strattera submitted to the agency by drug makers between January 1, 2000 and June 30, 2005. These symptoms came in children with “no identifiable risk factors, at usual doses of any of the drugs used to treat ADHD.” There was a “complete absence” of these ADHD medication side effects in children treated with dummy pills during clinical trials and in many children the symptoms stopped when the drugs were withdrawn and resumed when they were restarted. In addition to the case reports submitted by manufacturers, there were 560 reports of psychosis or mania submitted to the FDA via its MedWatch reporting system. It is estimated that only about 1% of adverse side effects are reported to the FDA. This suggests that over 100,000 children diagnosed with ADHD may have become psychotic or manic while taking ADHD drugs during this five- and-a-half year period. The same safety review reported “numerous postmarketing reports of aggression or violent behavior during drug therapy of ADHD.” In approximately 20% of the cases the behavior was considered life-threatening or required hospitalization. The majority of the reports of ADHD violent behavior were for children and adolescents, most of whom had “no specific risk factors for aggression or violent behavior.” According to the report, “a striking majority (80 to 90% overall) of patients … had no prior history of similar events.” Drug makers submitted over 1,400 reports of ADHD aggression or violent behavior, with over 700 additional cases reported to MedWatch. The FDA report establishes an unmistakable tie between ADHD medication and violence. In 2010, Thomas Moore, a senior scientist at the Institute for Safe Medical Practice (ISMP) and Joseph Glenmullen, a Clinical Instructor in Psychiatry at Harvard Medical School, published a joint study on prescription medication-induced violence, finding that 31 prescription medications are disproportionately linked to reports of violent behavior. In the study, Moore and Glenmullen extracted serious adverse event reports from the U.S. Food and Drug Administration (FDA) Adverse Event Reporting System, searching for any drugs with 200 or more case reports received from 2004 to 2009. They selected any reports that indicated homicide, homicidal ideation, physical assault, physical abuse or violence-related symptoms, and then used mathematical and statistical methods to identify drugs that were significantly more associated with those reports compared to other drugs. Out of 484 medications they evaluated, 31 (6%) were significantly more associated with violence. All but seven of the drugs were psychiatric drugs. The medications below were the most strongly associated with violent adverse events: Varenicline (Chantix, Fluoxetine (Prozac, Paroxetine (Paxil, Amphetamines, Mefoquine (Lariam, Atomoxetine (Strattera), Triazolam (Halcion), Fluvoxamine (Luvox), Venlafaxine (Effexor), Desvenlafaxine (Pristiq) Parents and the public have a right to know what psychiatric drugs do in the brain, the side effects of taking and withdrawing from these medications, and the medical basis — or lack thereof — behind the skyrocketing numbers of children being prescribed these drugs. Resources: https://www.baumhedlundlaw.com/medication-induced-violence/ https://www.druginjury.com/druginjurycom/2006/03/adderall_cardia.html https://journals.sagepub.com/doi/abs/10.1345/aph.1P172 For more information on this podcast, please visit www.adhdisover.com