FoundMyFitness #075 Intestinal Permeability: the Bacterial link to Aging, Brain Barrier Dysfunction & Metabolic Disorder
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May 31, 2022 Discover how intestinal permeability serves as a crucial gatekeeper to health, influencing everything from cardiometabolic function to brain health. Learn about the bacterial byproduct lipopolysaccharide and its surprising connections to chronic inflammation and disease. The role of diet, including the impact of alcohol and gluten, is examined alongside beneficial elements like butyrate and omega-3 fatty acids. This engaging discussion links gut health to cognitive decline and emphasizes the importance of maintaining gut integrity for overall well-being.
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Intestinal Permeability Definition
- Intestinal permeability is the disintegration of tight junctions in the intestinal lining.
- This allows bacterial products, bacteria, and food antigens to leak into circulation.
LPS and Atherosclerosis
- Lipopolysaccharide (LPS) binds to lipoproteins, which usually helps clear it from circulation.
- However, small, dense LDL particles with bound LPS can get stuck in the arterial wall, contributing to atherosclerosis.
LPS and Blood-Brain Barrier
- LPS can compromise the blood-brain barrier by shifting microglial cells from a protective to an attack mode.
- This leads to further breakdown of the barrier and neuroinflammation.