This Week in Cardiology Jul 11 2025 This Week in Cardiology
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Jul 11, 2025 Dive into the world of cardiology controversies, including the heated debate over ticagrelor's efficacy and safety in trials. Discover insights on the longevity of ICD batteries and what it means for patient care. The PRAGUE-25 trial is highlighted as a pivotal study this year, stimulating discussions on the future of electrophysiology as a profession. The episode also features personal anecdotes blending professional insights with lighthearted moments from recent celebrations.
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Mandrola's Holiday Fireworks Anecdote
- John Mandrola shares a personal holiday memory watching grandchildren enjoy fireworks.
- He humorously notes becoming a Kentuckian pickup truck owner because of this experience.
Timing Matters in PE Trials
- Early interventional PE devices lacked sufficient expertise and data, explaining initial negative trial results.
- Now RCTs are possible as expertise has grown, reflecting the importance of timing in clinical research.
FDA Device Approval Challenges
- Restricting first-generation device studies risks hindering innovation and progress.
- However, current FDA 510K approval pathway allowing device approval by similarity is problematic and needs reform.