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Cardionerds: A Cardiology Podcast
406. Journal Club: The BPROAD Trial with Dr. Keith Ferdinand
Jan 15, 2025
Dr. Keith Ferdinand, a leading expert in hypertension at Tulane University, joins hosts to discuss the groundbreaking BPROAD trial. They explore the impact of intensive blood pressure management on cardiovascular outcomes in patients with type 2 diabetes. The conversation highlights the trade-offs of rigorous blood pressure targets and strategies for managing uncontrolled hypertension. Future directions in treatment, including cognitive health implications and advanced therapies like renal denervation, add to the intrigue, promising exciting developments in cardiovascular care.
26:41
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Quick takeaways
- Intensive blood pressure control in patients with type 2 diabetes can significantly lower major adverse cardiovascular events, particularly stroke incidents.
- Current U.S. guidelines recommending a blood pressure target below 130 mmHg are supported by trial findings, which suggest even lower targets may be beneficial.
Deep dives
Intensive Blood Pressure Control Benefits
Intensive blood pressure control in patients with type 2 diabetes significantly reduces major adverse cardiovascular events (MACE). A recent trial demonstrated that lowering systolic blood pressure to less than 120 mmHg resulted in a 21% lower relative risk of MACE compared to a standard target of 140 mmHg. This reduction was primarily attributed to a decrease in stroke incidents, highlighting the importance of aggressive hypertension management in high-risk populations. The trial underscored previous guidelines suggesting that achieving a blood pressure below 130 could confer similar benefits, thus reinforcing the need for clinicians to aim for lower targets in line with emerging evidence.
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