Sam Harris hosts James Fadiman, a Harvard and Stanford-educated psychologist and early psychedelic researcher, known for his work in microdosing. They delve into who should safely take psychedelics and the crucial aspect of 'set and setting.' Fadiman shares insights on microdosing's antidepressant properties and cognitive benefits. They explore the distinctions between MDMA and true psychedelics, the transformative effects of psychedelics on self-identity, and the necessity of compassionate guidance in these experiences.