VJHemOnc Podcast
Novel developments in lower-risk MDS & important practical considerations when treating patients
Jul 15, 2024
In this insightful discussion, Amer Zeidan from Yale and Rena Buckstein from Sunnybrook share their expert views on treating lower-risk myelodysplastic syndromes (MDS). They highlight the importance of accurate diagnosis with bone marrow examinations and prognostic tools. Guillermo Garcia-Manero from MD Anderson dives into innovative treatments like erythropoiesis-stimulating agents and Luspatercept, while Andrew Brunner emphasizes the complexities of dosing. They advocate for improved strategies and collaboration to enhance patient care and outcomes.
51:43
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Quick takeaways
- The evaluation of patients with lower-risk MDS requires comprehensive diagnostic tools to ensure accurate treatment decisions and reduce clinical discrepancies.
- Emerging therapies like luspatercept present significant potential for improving patient quality of life and reducing transfusion dependency in lower-risk MDS.
Deep dives
Current Approaches to Lower Risk MDS Treatment
The evaluation of patients with lower risk myelodysplastic syndromes (MDS) often begins with a bone marrow examination to confirm diagnosis, as discrepancies in diagnosis can occur across institutions. Prognostic tools, such as the IPSSR and genomic data from tests like IPSSM, are used to assess risk factors including age, cytopenia levels, and transfusion dependency. This multifaceted approach allows physicians to determine whether a patient should be observed or treated with therapies such as growth factors or lenalidomide. The discussion highlights the importance of individualizing treatment plans based on a patient's comprehensive health profile and the heterogeneity of the disease.
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