Critical Matters

PADIS Guidelines Update

Apr 24, 2025
Joanna L. Stollings, PharmD, is a critical care pharmacotherapy expert at Vanderbilt University Medical Center and co-chair of the updated PADIS guidelines. In this engaging discussion, she dives into the crucial updates on managing pain, anxiety, and sedation in ICU patients. Joanna emphasizes the need for improved assessment tools for anxiety and highlights the shift towards dexmedetomidine for sedation. She also explores the advancements in delirium treatment, innovations in alcohol withdrawal management, and the significance of post-ICU care to enhance patient recovery.
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INSIGHT

Importance of Treating Pain and Delirium

  • Treating pain and delirium is crucial in ICU care due to significant negative patient outcomes.
  • Delirium increases mortality risk, cognitive impairment, ICU stay, and healthcare costs.
INSIGHT

2018 PADIS Guidelines Highlights

  • The 2018 PADIS guidelines expanded prior PADS guidelines by including early mobility and sleep disruption.
  • They recommended specific analgesics and sedatives and discouraged antipsychotics for delirium treatment.
INSIGHT

Focused Updates Accelerate Improvements

  • Society of Critical Care Medicine now issues focused updates more frequently to address emerging evidence quickly.
  • The latest update selectively addressed five key clinical questions after evidence review.
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