The Antioxidant of Antioxidants: A Compound You're Not Paying Attention To

In this episode of Daily Value, we look at the often overlooked yet potent nutrient, alpha lipoic acid, which is integral to mitochondrial energy metabolism and cellular health. Discovered in 1937, ALA acts as a primary antioxidant in the body. This episode covers the distinction(s) between supplemental and endogenous ALA. The latter is able to cross the blood-brain barrier and is used therapeutically for conditions like diabetic neuropathy, oxidative stress, and metal detoxification. I will also explain the importance of selecting the right form of ALA , recommended dosages for different formulations and their potential benefits in metabolic health.

00:00 Introduction to Alpha Lipoic Acid

00:53 Discovery and Biological Role

02:05 Antioxidant Properties and Functions

03:28 Supplemental Benefits and Research

06:28 Forms and Bioavailability

09:52 Therapeutic Threshold and Dosing

11:27 Safety and Efficacy

13:14 Conclusion and Recommendations

PMID: 39456481

PMID: 18069903

PMID: 29191830

PMID: 25971966